In vivo EGF stimulates keratinocyte proliferation during the proliferative phases of wound healing [1]. EGF was first discovered by Dr Stanley Cohen and has been used to treat severe burns by augmenting epithelial growth.

Dr. Cohen furthermore discovered, isolated, purified, and sequenced epidermal growth factor (EGF), a protein that stimulates the growth of epithelial and other cells and enhances certain developmental growth cascades. Once the sequence was known, he was able to identify the target receptor for EGF and the mechanism of its action, providing a breakthrough in understanding how signals from outside a cell reach the inside of a cell.

In 1986, Dr. Cohen and Dr. Levi-Montalcini both earned the Nobel Prize in Physiology or Medicine and the Albert Lasker Basic Medical Research Award for their discoveries related to growth factors.

 

As a person ages, the amount of EGF in his/her skin diminishes which lengthens the cell cycle. Generally, a cell cycle would be 20 days for a 10-year-old, 28 days for a 20-year-old and 40 days for a 40-year-old. With the Conc. EGF in Derml products, the amount of EGF is highest amongst all popular cosmetic and skincare products, and has been coined as the "King of EGF" in Japan.